Katherine Marie Heigl ( born November 24, 1978) is an American actress and producer. She is possibly best known for her role as Dr. Isobel "Izzie" Stevens on ABC's medical drama Grey's Anatomy from 2005 to 2010, for which she won the Primetime Emmy Award for Outstanding Supporting Actress in a Drama Series in 2007. She has also starred in films such as Under Siege 2: Dark Territory, Zyzzyx Road, Knocked Up, 27 Dresses, The Ugly Truth, Killers, Life As We Know It, New Year's Eve, and One for the Money.