Meghna was born in the Naidu family on September 19, 1980 in Vijayawada, Andhra Pradesh, India. Her first major appearance was in the music video for UMI10's "Kaliyon Ka Chaman" (2000), an official remix of Lata Mangeshkar's 1981 song "Thoda Resham Lagta Hai" (in turn, the 2002 song "Addictive" by Truth Hurts was inspired by the remix). She also featured in Saru Maini's video Dil De Diya Tha (Sutta Mix), before eventually working in Indian films. As of September, 2007, she is also slated to act in Telugu and Malyalam language movies, including one titled 'Chandrika', and hopes to shed off her glamorized image in Ashok Nanda's movie titled 'Riwaaz'.